Subtilisin

Subtilisin is a proteolytic enzyme produced by Bacillus species through biotechnology. In skincare, it works as a pH-dependent enzymatic exfoliant, loosening protein-rich surface buildup to leave rinse-off masks and cleansers feeling smoother.
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Ingredient Snapshot

Overview
An enzyme that gently dissolves buildup for smoother-feeling skin.
Category
Exfoliating, Tone/Texture
Type
Exfoliant

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

It gently refines roughness to reveal a more polished, even-feeling complexion with minimal mechanical rubbing, though evidence for long-term skin benefits in leave-on products is limited.

Uses In Skincare & Cosmetics

It's often included in enzyme peels, exfoliating gels, and powder-to-foam treatments that are rinsed after short contact.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

It may cause stinging, redness, or tightness, especially on sensitive or compromised skin and around the eyes; rinse-off use typically lowers this risk. Patch test if you're reactive and avoid using it alongside other strong exfoliants.

Is Subtilisin a Good Ingredient?

It rates Fair because its enzymatic exfoliation can smooth texture in short-contact formulas, but strong clinical data for leave-on benefits are limited. As a protease, it may also irritate or disrupt the barrier if overused or at unsuitable pH.

Products with Subtilisin

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