Snapshot
- Overview
- An enzyme that gently dissolves buildup for smoother-feeling skin.
- Category
- Exfoliating, Tone/Texture
- Type
- Exfoliant
Subtilisin
Subtilisin is a proteolytic enzyme produced by Bacillus species through biotechnology. In skincare, it works as a pH-dependent enzymatic exfoliant, loosening protein-rich surface buildup to leave rinse-off masks and cleansers feeling smoother.
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Our take
Is Subtilisin a Good Ingredient?
It rates Fair because its enzymatic exfoliation can smooth texture in short-contact formulas, but strong clinical data for leave-on benefits are limited. As a protease, it may also irritate or disrupt the barrier if overused or at unsuitable pH.
What it does
Skin Benefits
It gently refines roughness to reveal a more polished, even-feeling complexion with minimal mechanical rubbing, though evidence for long-term skin benefits in leave-on products is limited.
Where you'll find it
Uses in Skincare & Cosmetics
It's often included in enzyme peels, exfoliating gels, and powder-to-foam treatments that are rinsed after short contact.
Before you use it
Safety
It may cause stinging, redness, or tightness, especially on sensitive or compromised skin and around the eyes; rinse-off use typically lowers this risk. Patch test if you're reactive and avoid using it alongside other strong exfoliants.
Products with Subtilisin
