Lipase

Lipase is a biotechnology-derived enzyme that breaks down skin-surface triglycerides into smaller components. Oil-control cleansers and enzyme treatments use it to loosen sebum buildup and improve feel, provided the formula's pH supports its activity.
Like this ingredient?

Ingredient Snapshot

Overview
An enzyme that breaks down excess oil to help skin feel less greasy.
Category
Cleansing, Oil Control
Type
Exfoliant

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

Helps break down excess surface oils to reduce greasiness and improve skin clarity when used under the right conditions, though the evidence is moderate and activity depends on pH and formula design.

Uses In Skincare & Cosmetics

Used in enzyme cleansers, oil-control face washes, and exfoliating masks or pads.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

May cause mild irritation or stinging, especially on compromised skin or with prolonged contact; avoid the eye area and overexfoliation. Patch testing is advisable for sensitive users.

Is Lipase a Good Ingredient?

Fair fits because the sebum-breakdown benefit is real but conditional: performance is highly pH- and formula-dependent, and human data are limited. Overuse or the wrong conditions can also lead to irritation.