S-Palmitoylglutathione

S-Palmitoylglutathione is a palmitoylated, oil-dispersible derivative of the endogenous tripeptide glutathione. It's added to skincare for antioxidant support in lipid phases and to improve formula stability, though published data remain modest.
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Ingredient Snapshot

Overview
This glutathione derivative fights free radicals for glowing skin.
Category
Antioxidant, Anti-aging, Skin Conditioning
Type
Antioxidant

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

Helps defend against free-radical stress to maintain a smoother, more luminous appearance, though current clinical support is modest. Can support skin's resilience when used consistently.

Uses In Skincare & Cosmetics

Often included in oil-based serums, creams, facial oils, and some sunscreens to bolster antioxidative protection in the lipid phase.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Typically low irritation, though sensitive skin may notice mild stinging or redness. No widely recognized regulatory restrictions; patch test if easily reactive.

Is S-Palmitoylglutathione a Good Ingredient?

Fair, because while the lipid-soluble form improves stability and delivery compared to plain glutathione, peer-reviewed clinical data on visible outcomes stays modest. Some individuals may also experience mild irritation or breakouts with richer, oil-phase antioxidants like this one.

Products with S-Palmitoylglutathione

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