Oxidized Glutathione

Oxidized glutathione (GSSG) is the disulfide form of the tripeptide glutathione, in its oxidized redox state. It's used to support antioxidant capacity and turns up in brightening lines, though evidence for clear topical effects is limited.
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Ingredient Snapshot

Overview
An antioxidant form of glutathione used in brightening products.
Category
Antioxidant, Brightening
Type
Antioxidant

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

Helps defend skin against surface oxidative stress and may promote a more even-looking complexion. Evidence for visible brightening from topical use is limited.

Uses In Skincare & Cosmetics

Appears in serums, essences, and sheet masks aimed at dullness or environmental exposure. Commonly paired with antioxidants like vitamin C in lightweight water-based formulas.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Typically low irritation, though peptides can occasionally trigger stinging or redness in reactive skin. Limited human data on long-term topical use, so introduce gradually if sensitive.

Is Oxidized Glutathione a Good Ingredient?

Rated Fair: it has theoretical antioxidant support, but clinical data for visible brightening from topical use remains limited, and mild irritation is possible for very sensitive users, which together keep it from a Good rating.

Products with Oxidized Glutathione

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