Acetyl Tetrapeptide-5

Acetyl Tetrapeptide-5 is a man-made four-amino-acid peptide frequently used in eye-area cosmetics. It's included to calm and reduce the look of under-eye puffiness and shadows, though the supporting research is only fair in quality.
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Ingredient Snapshot

Overview
Used around the eyes to calm puffiness and dark circles.
Category
Soothing, Anti-aging, Skin Conditioning
Type
Peptide

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

Can provide a soothing feel and diminish the look of morning puffiness around the eyes. Evidence is limited, so results vary and are often mild.

Uses In Skincare & Cosmetics

Common in eye gels, roll-on eye serums, and under-eye sheet patches for quick refresh. Also appears in lightweight daytime eye creams.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Generally well tolerated for eye-area use, though transient stinging or redness can occur if it enters the eyes or on sensitive skin. No widely recognized regulatory restrictions at typical levels.

Is Acetyl Tetrapeptide-5 a Good Ingredient?

It rates Fair because benefits for under-eye puffiness rely largely on supplier studies, with modest, temporary effects. A small risk of irritation exists if product migrates into the eyes or on very delicate skin.

Products with Acetyl Tetrapeptide-5

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