4.5 kDa Hydroxypropyltrimonium Hyaluronate

4.5 kDa Hydroxypropyltrimonium Hyaluronate is a cationic, low-molecular-weight hyaluronic acid derivative that's water-soluble and film-forming. Skincare formulas use it to attract moisture, condition the surface, and improve feel and wear.
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Ingredient Snapshot

Overview
A lightweight hyaluronic acid that hydrates and smooths skin fast.
Category
Hydration, Skin Conditioning, Barrier Support
Type
Humectant

Ingredient Ratings

Overall Rating

Great

Comedogenic Risk

None

Skin Benefits

Delivers quick, deep-feeling hydration that leaves skin looking plumper and smoother. Helps reduce the sensation of tightness and keeps moisture feeling locked in through the day.

Uses In Skincare & Cosmetics

Common in lightweight serums, essences, and sheet masks to boost water retention. Also used in leave‑on moisturizers to improve slip and a soft-touch finish.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Considered well tolerated for most users, with a low likelihood of irritation. Suitable for daily use in leave-on products; avoid use on compromised skin if sensitivity occurs.

Is 4.5 kDa Hydroxypropyltrimonium Hyaluronate a Good Ingredient?

Rated Great, because this low–molecular-weight, cationic HA derivative shows well-documented hydration benefits, adheres well to skin, and is typically stable in water-based formulas. It is generally low–irritation and helps improve moisture retention without heaviness.

Products with 4.5 kDa Hydroxypropyltrimonium Hyaluronate

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