Tetrapeptide-21

Tetrapeptide-21 is a synthetic peptide made of four amino acids designed for cosmetic use. Formulators use it to improve the look of skin smoothness and tone; current support comes mainly from limited manufacturer studies.
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Ingredient Snapshot

Overview
A synthetic peptide meant to refine skin's smoothness and tone.
Category
Anti-aging, Skin Conditioning, Tone/Texture
Type
Peptide

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

Helps refine skin texture and supports a smoother-looking complexion; backing is limited and mainly from supplier testing.

Uses In Skincare & Cosmetics

Used in anti-aging serums, lotions, and eye creams targeting fine lines and an uneven look.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Typically well tolerated, though peptides can occasionally cause transient redness or tingling, especially near the eyes or on compromised skin. No widely recognized regulatory limits at standard cosmetic concentrations.

Is Tetrapeptide-21 a Good Ingredient?

It rates Fair due to limited independent clinical evidence, since most performance claims come from small supplier studies. A minority of users may experience mild irritation or sensitization, and results depend heavily on the formula.

Products with Tetrapeptide-21

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