Tetrapeptide-2

Tetrapeptide-2 is a synthetic four-amino-acid peptide compatible with aqueous, leave-on skincare. It's added to serums and creams for a firmer feel and a more refined look, but confirmation from solid independent studies is limited.
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Ingredient Snapshot

Overview
A synthetic peptide meant to give skin a firmer, more refined look.
Category
Anti-aging, Firming, Skin Conditioning
Type
Peptide

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

May help skin feel firmer and improve the look of laxity, though available clinical support is modest.

Uses In Skincare & Cosmetics

Included in firming serums, neck creams, and eye lotions aimed at a more lifted, toned appearance.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Typically safe for routine use and not known to be photosensitizing. Patch test if prone to reactivity. No specific cosmetic regulatory limitations are commonly cited.

Is Tetrapeptide-2 a Good Ingredient?

It's Fair because firmness and lifting claims rest on limited studies, so real-world effects may be subtle rather than dramatic. Minor irritation or redness can also occur in sensitive individuals.