Tetrapeptide-16

Tetrapeptide-16 is a lab-designed short chain of four amino acids used in topical formulations. It's included to support skin comfort and reduce the look of reactivity, with evidence still emerging.
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Ingredient Snapshot

Overview
May help ease the look of redness and irritation in reactive skin.
Category
Soothing, Sensitive Skin, Skin Conditioning
Type
Peptide

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

May help soothe the feel of irritation and lessen the look of redness; current evidence remains preliminary.

Uses In Skincare & Cosmetics

Often included in calming serums, moisturizers, and after-sun gels for easily upset complexions.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Generally considered low-irritant, but peptide actives can trigger stinging or redness in very reactive skin, so patch test if you're easily sensitized. No specific regulatory restrictions are commonly cited for cosmetic use at typical levels.

Is Tetrapeptide-16 a Good Ingredient?

It rates Fair because support comes mostly from preliminary or supplier-led data, so real-world benefits for redness and comfort aren't yet well established. Some users may be sensitive to the peptide or its carrier system, so outcomes can vary by formula.

Products with Tetrapeptide-16

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