Sh-Polypeptide-50 is a laboratory-produced, water-soluble peptide made through biotechnology. It's added to condition skin and improve surface feel; data are preliminary, and performance varies with use level.
A lab-made peptide that conditions skin for a smoother surface.
Category
Skin Conditioning, Anti-aging, Tone/Texture
Type
Peptide
Ratings
Overall Rating
Fair
Comedogenic Risk
None
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Sh-Polypeptide-50 a Good Ingredient?
The Fair rating reflects how preliminary the data still is: real-world efficacy is uncertain, and whatever benefit shows up is likely to be subtle and formula-dependent rather than reliable. Some users also report mild stinging or redness.
What it does
Skin Benefits
Used consistently, it aims to improve softness and give skin a velvety finish. The evidence for this is still preliminary, so any change is likely to be incremental.
Where you'll find it
Uses in Skincare & Cosmetics
It's used in moisturizers, leave-on masks, and makeup-priming lotions to smooth the skin before application.
Before you use it
Safety
There are no known ingredient-specific regulatory restrictions, and standard cosmetic use is considered low risk. Minor irritation can happen, particularly on compromised skin, so avoid applying it to broken or freshly exfoliated areas.