Sh-Polypeptide-50 is a laboratory-produced, water-soluble peptide made through biotechnology. It's added to condition skin and improve surface feel; data are preliminary, and performance varies with use level.
A lab-made peptide that conditions skin for a smoother surface.
Category
Skin Conditioning, Anti-aging, Tone/Texture
Type
Peptide
Ingredient Ratings
Overall Rating
Fair
Comedogenic Risk
None
Skin Benefits
Used consistently, it aims to improve softness and give skin a velvety finish. The evidence for this is still preliminary, so any change is likely to be incremental.
Uses In Skincare & Cosmetics
It's used in moisturizers, leave-on masks, and makeup-priming lotions to smooth the skin before application.
Comedogenic Rating
This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.
Safety
There are no known ingredient-specific regulatory restrictions, and standard cosmetic use is considered low risk. Minor irritation can happen, particularly on compromised skin, so avoid applying it to broken or freshly exfoliated areas.
Is Sh-Polypeptide-50 a Good Ingredient?
The Fair rating reflects how preliminary the data still is: real-world efficacy is uncertain, and whatever benefit shows up is likely to be subtle and formula-dependent rather than reliable. Some users also report mild stinging or redness.