Sh-Polypeptide-121

Sh-Polypeptide-121 is a recombinant, water-soluble cosmetic peptide. It's included to support skin conditioning and refine visible tone and texture; evidence is limited, and effectiveness depends on the formulation.
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Ingredient Snapshot

Overview
A recombinant peptide used to condition skin and even out texture.
Category
Skin Conditioning, Anti-aging, Tone/Texture
Type
Peptide

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

Over time it can promote a more supple feel and a more even-looking complexion, though results vary with concentration and how it's delivered in the formula.

Uses In Skincare & Cosmetics

It appears in serums and lotions, and occasionally in toners meant for layering into multi-step routines.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

It's considered low risk for most users, though peptides and the preservatives that accompany them can irritate sensitive skin. Patch testing is advisable, and it isn't associated with phototoxic effects.

Is Sh-Polypeptide-121 a Good Ingredient?

Clinical substantiation for this recombinant peptide is limited, and performance shifts with dose and delivery system, which is why it lands at Fair rather than higher. There's also a low but real risk of sensitivity reactions.

Products with Sh-Polypeptide-121

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