Sh-Pentapeptide-19

Sh-Pentapeptide-19 is a biotechnology-derived, water-soluble pentapeptide modeled on a short human protein fragment. It's used in skincare to condition skin and improve the look of firmness and texture, though evidence is limited and results vary.
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Ingredient Snapshot

Overview
A lab-made peptide that may soften lines and add bounce.
Category
Anti-aging, Firming, Skin Conditioning, Tone/Texture
Type
Peptide

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

May soften the look of fine lines and help skin feel bouncier, though available studies are early and effects can be subtle.

Uses In Skincare & Cosmetics

Often included in lightweight serums or eye creams targeting a smoother finish; sometimes blended into moisturizers to layer under makeup.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Generally considered low-irritant in leave-on products, but patch testing is sensible if you're sensitive. Mild redness or stinging can occur; discontinue if irritation persists. No well-established regulatory restrictions noted.

Is Sh-Pentapeptide-19 a Good Ingredient?

Fair, because the evidence is preliminary with inconsistent performance across users, so any smoothing or firming effect tends to be modest. A small risk of irritation or sensitization also exists, especially for very reactive skin.

Products with Sh-Pentapeptide-19

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