Protease

Protease is a protein-cleaving enzyme derived from microbes, plants, or fermentation for topical use. It's included in exfoliating formulas to loosen surface buildup and refine texture, though performance is pH-dependent and human cosmetic evidence is limited.
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Ingredient Snapshot

Overview
An enzyme that breaks down buildup to smooth and refine skin texture.
Category
Exfoliating, Tone/Texture
Type
Exfoliant

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

Helps smooth the skin’s surface by dissolving buildup of dead proteins, revealing a more refined look; results can vary with pH and formula. Evidence for long-term skin improvements is limited.

Uses In Skincare & Cosmetics

Found in exfoliating cleansers, peel gels, and wash-off masks designed for gentle resurfacing. Occasionally included in serums or toners formulated for enzyme-based renewal.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Irritation or stinging can occur, especially at lower pH, higher activity, or with overuse; patch test and avoid broken or compromised skin. Use alongside moisturizers and limit frequency if sensitivity appears.

Is Protease a Good Ingredient?

It rates Fair: it can help surface exfoliation, but benefits depend on pH and enzyme activity, and evidence for lasting results is limited; misuse or high activity may irritate or disrupt the barrier.

Products with Protease

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