Polyquaternium-51

Polyquaternium-51 is a biomimetic, water-soluble phospholipid polymer that forms a moisture-retentive film. It boosts water retention and comfort, and makes formulas gentler, which is why it shows up often in hydrating and soothing products.
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Ingredient Snapshot

Overview
A hydrating polymer that keeps skin cushioned and comfortable.
Category
Hydration, Barrier Support, Sensitive Skin, Skin Conditioning
Type
Film Former

Ingredient Ratings

Overall Rating

Great

Comedogenic Risk

None

Skin Benefits

Provides a lasting hydration feel and helps skin feel cushioned, reducing sensations of tightness. Often well-tolerated, making it appealing for easily irritated skin.

Uses In Skincare & Cosmetics

Featured in hydrating serums, moisturizers, and sheet masks to boost moisture comfort. Also used in eye creams and after-sun gels for a dewy, soothing finish.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Typically well tolerated with a low likelihood of irritation, including for dry or reactive skin types. As with any ingredient, rare sensitivity can occur; discontinue if irritation appears. No widely recognized regulatory limits for standard cosmetic use.

Is Polyquaternium-51 a Good Ingredient?

Rated Great because biomimetic hydration performance has been supported by in vivo and in-use studies showing improved moisture retention with a gentle profile. It is stable in water-based formulas and is typically well tolerated, making it appealing for sensitive routines.

Products with Polyquaternium-51

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