Polypeptide-121

Polypeptide-121 is a biotechnology-derived synthetic polypeptide used in cosmetic formulations. It's included for skin conditioning and texture refinement, improving cosmetic feel and appearance, though consumer-facing evidence is still limited.
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Ingredient Snapshot

Overview
A lab-made peptide used to smooth and refine the look of skin.
Category
Skin Conditioning, Tone/Texture
Type
Peptide

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

May help skin feel smoother and look more refined; current cosmetic evidence is limited. Provides conditioning that can soften the look of uneven texture.

Uses In Skincare & Cosmetics

Used in peptide-focused serums, moisturizers, and eye creams aimed at improving surface feel. Also appears in leave-on treatments targeting a polished finish.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Generally considered low risk, yet peptides and their carriers can occasionally irritate reactive skin. Patch testing is prudent. Avoid use on compromised or freshly exfoliated skin if sensitivity occurs.

Is Polypeptide-121 a Good Ingredient?

It's a promising conditioning peptide, but current cosmetic evidence is limited, so results may be modest, which keeps it at Fair; some users, especially very sensitive skin, could experience mild irritation.

Products with Polypeptide-121

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