Pentapeptide-18

Pentapeptide-18 is a synthetic, water-soluble chain of five amino acids used in cosmetic formulations. Age-care and texture-focused products include it to support surface conditioning and a smoother look, though independent evidence is limited.
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Ingredient Snapshot

Overview
A peptide used in anti-aging products to soften expression lines.
Category
Anti-aging, Tone/Texture
Type
Peptide

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

May soften the appearance of expression lines and support a more refined complexion; available cosmetic evidence is modest.

Uses In Skincare & Cosmetics

Included in lightweight serums, eye gels, and moisturizers aimed at age-care routines and texture-focused regimens.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Typically well tolerated, though mild stinging or redness can occur; patch testing is advisable, especially near the eyes. If irritation appears, reduce frequency or simplify other actives.

Is Pentapeptide-18 a Good Ingredient?

Rated Fair: the evidence for expression-line softening is limited and largely supplier-driven, so benefits may be modest. Irritation risk is low but possible, particularly for sensitive or eye-area use, which is enough to hold it below Good.

Products with Pentapeptide-18

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