Oligopeptide-29 is a lab-synthesized short-chain peptide used in topical cosmetic products, added to serums and creams to condition skin feel and improve surface smoothness, though independent evidence for distinct effects remains limited.
A peptide meant to smooth skin's surface, though evidence is thin.
Category
Skin Conditioning, Tone/Texture
Type
Peptide
Ratings
Overall Rating
Fair
Comedogenic Risk
None
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Oligopeptide-29 a Good Ingredient?
Rated Fair due to limited peer-reviewed data on any unique skin benefit, with performance depending heavily on the vehicle it's formulated in. Irritation is generally low, but sensitivities can occur in complex formulas, which is enough to keep it out of Good territory.
What it does
Skin Benefits
May support a smoother-feeling surface and a softer appearance; current research is sparse. Visible changes, if any, are typically modest and formula-dependent.
Where you'll find it
Uses in Skincare & Cosmetics
Used in serums, essences, and moisturizers to boost slip and elegant application. Also appears in leave-on treatments aimed at refined skin feel.
Before you use it
Safety
Generally considered low risk in topical use. Patch test if reactive or when layering multiple actives. No specific regulatory restrictions are widely cited for this peptide.