Nicotiana benthamiana hexapeptide-40 sh-polypeptide-76 is a plant-expressed peptide fragment generated through biotechnology. Formulators use it for firmer tone and improved skin look, though current human clinical support for topical use is sparse.
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76 a Good Ingredient?
It's included for firming and texture support, yet topical human data remain limited, which is why it rates Fair; results are uncertain and typically subtle without complementary actives.
What it does
Skin Benefits
Can lend a subtly more elastic, smoother appearance, though published human data are sparse and effects may be modest; works best alongside proven actives.
Where you'll find it
Uses in Skincare & Cosmetics
Frequently incorporated into firming creams, ampoules, and eye gels, and sometimes added to serums aimed at tone and texture refinement.
Before you use it
Safety
Typically low risk of irritation, though peptide fragments may cause sensitivity in susceptible individuals. Patch test before regular use and avoid broken or inflamed skin.
Products with Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-76