Hydroxypalmitoyl Sphinganine

Hydroxypalmitoyl sphinganine is a ceramide-related lipid derived from sphingoid bases. It supports the skin barrier and boosts moisturization in leave-on products, with strong industry backing and emerging clinical data.
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Ingredient Snapshot

Overview
A ceramide-like lipid that strengthens the skin barrier and hydrates.
Category
Barrier Support, Skin Conditioning, Sensitive Skin
Type
Emollient

Ingredient Ratings

Overall Rating

Great

Comedogenic Risk

None

Skin Benefits

Improves moisture retention and helps reduce dryness for a smoother, more resilient skin feel.

Uses In Skincare & Cosmetics

Found in barrier creams, rich moisturizers, and sensitive-skin serums aimed at dehydration and a weakened barrier.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Widely well tolerated with a low irritation profile, including for sensitive skin types. Patch test if extremely reactive; no notable regulatory restrictions reported.

Is Hydroxypalmitoyl Sphinganine a Good Ingredient?

Rated Great as a ceramide-related lipid backed by supportive clinical and industry data for barrier reinforcement and reducing water loss, with good stability and typically low irritation, a strong combination for a barrier-focused ingredient.

Products with Hydroxypalmitoyl Sphinganine

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