Guanosine

Guanosine is a water-soluble purine nucleoside found in RNA and used as a cosmetic humectant. In formulas it's included to attract moisture, support a smoother feel, and refine product sensory qualities, with limited evidence for skin-conditioning roles.
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Ingredient Snapshot

Overview
An RNA-derived humectant that plumps skin and smooths its surface.
Category
Hydration, Skin Conditioning, Tone/Texture
Type
Humectant

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

Draws water to the skin for a plumper, softer feel and a more refined surface. Evidence for broader skin benefits is limited, so results may be subtle.

Uses In Skincare & Cosmetics

Included in lightweight serums, toners, and gel moisturizers to boost hydration without heaviness, and in creams to improve slip and afterfeel.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Generally well tolerated as a water-soluble humectant, with low likelihood of irritation. Patch test if skin is sensitive or compromised. No known specific regulatory restrictions at typical cosmetic levels.

Is Guanosine a Good Ingredient?

It's Fair because clinical evidence for topical benefits beyond basic humectancy is limited, so effects are likely modest. Minor irritation is uncommon but possible, especially at high concentrations or on compromised skin, which is enough to keep it out of Good.

Products with Guanosine

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