A simple dipeptide composed of two glycine units, readily soluble in water and compatible with aqueous systems. It's used to adjust pH and support stability, with limited evidence for direct skin-conditioning.
A simple dipeptide that helps balance formulas and smooth skin's feel.
Category
Skin Conditioning
Type
Buffer
Ratings
Overall Rating
Fair
Comedogenic Risk
None
Not typically evaluated for comedogenicity — no standardized rating available.
Our take
Is Glycylglycine a Good Ingredient?
It's Fair because it functions mainly as a pH-buffering dipeptide, and evidence for direct skin benefits beyond that is limited. At higher levels it can shift product pH and may cause minor stinging in sensitive skin, which is what keeps the rating in the middle.
What it does
Skin Benefits
May help skin feel smoother and more comfortable by supporting a balanced environment; evidence for direct skin benefits is limited. Contributes to a more consistent feel in products used daily.
Where you'll find it
Uses in Skincare & Cosmetics
Commonly used in water-based serums, toners, and essences as a pH-buffering component. Also appears in gel creams to help maintain formula performance over time.
Before you use it
Safety
Typically low risk at cosmetic use levels, though mild, transient irritation can occur. No widely recognized topical regulatory restrictions.