Cetylhydroxyproline Palmitamide

Cetylhydroxyproline Palmitamide is a pseudo-ceramide lipid amide from hydroxyproline and palmitic acid used as an emollient. It's used to mimic skin lipids, curb moisture loss, increase suppleness, and leave a smooth, conditioned finish.
Like this ingredient?

Snapshot

Overview
A ceramide-like lipid that reinforces the skin barrier and eases dryness.
Category
Barrier Support, Skin Conditioning, Hydration
Type
Emollient

Ratings

Overall Rating

Good

Comedogenic Risk

None

Not typically evaluated for comedogenicity — no standardized rating available.

Is Cetylhydroxyproline Palmitamide a Good Ingredient?

This pseudo‑ceramide emollient helps support barrier lipids and reduce moisture loss, with some supportive data and a low tendency to irritate. That combination of solid performance and generally low risk earns it a Good rating, short of Great.

Skin Benefits

Helps reinforce the skin’s protective layer, easing feelings of dryness and tightness. Leaves skin feeling supple and more comfortable.

Uses in Skincare & Cosmetics

Common in rich creams, balms, and overnight masks to cushion the skin; also appears in eye creams targeting delicate areas.

Safety

Generally well tolerated; fatty amide structures are unlikely to irritate, though rare individuals may experience sensitivity. Appropriate for daily leave‑on use unless irritation occurs.