Biotinoyl Hexapeptide-2 Amide

Biotinoyl Hexapeptide-2 Amide is a synthetic, water-soluble hexapeptide acylated with biotin for cosmetic use. Lash, brow, and scalp formulas use it to condition fibers, support a fuller-looking appearance, and act as a signaling peptide.
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Snapshot

Overview
A peptide used in lash and brow products to condition fibers.
Category
Skin Conditioning
Type
Peptide

Ratings

Overall Rating

Fair

Comedogenic Risk

None

Not typically evaluated for comedogenicity — no standardized rating available.

Is Biotinoyl Hexapeptide-2 Amide a Good Ingredient?

Evidence for visibly strengthening lashes and brows is mostly marketing-driven or small-scale, so results may be subtle, which is why it's rated Fair. Eye-area use can also pose a slight irritation risk for sensitive users.

Skin Benefits

Helps lashes, brows, and hair fibers feel conditioned and appear less brittle, supporting a fuller-looking appearance and improving the feel of density and suppleness over time; evidence for dramatic effects is limited.

Uses in Skincare & Cosmetics

Frequently formulated into lash serums, brow gels, and scalp leave-ons, and also used in conditioning mascaras and brow pomades.

Safety

Typically well tolerated, but peptides and eye-area formulas can cause stinging or redness in some. Patch test on the lash line perimeter first, and avoid direct contact with the eyes.