Biotinoyl Hexapeptide-2 Amide

Biotinoyl Hexapeptide-2 Amide is a synthetic, water-soluble hexapeptide acylated with biotin for cosmetic use. Lash, brow, and scalp formulas use it to condition fibers, support a fuller-looking appearance, and act as a signaling peptide.
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Ingredient Snapshot

Overview
A peptide used in lash and brow products to condition fibers.
Category
Skin Conditioning
Type
Peptide

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

Helps lashes, brows, and hair fibers feel conditioned and appear less brittle, supporting a fuller-looking appearance and improving the feel of density and suppleness over time; evidence for dramatic effects is limited.

Uses In Skincare & Cosmetics

Frequently formulated into lash serums, brow gels, and scalp leave-ons, and also used in conditioning mascaras and brow pomades.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Typically well tolerated, but peptides and eye-area formulas can cause stinging or redness in some. Patch test on the lash line perimeter first, and avoid direct contact with the eyes.

Is Biotinoyl Hexapeptide-2 Amide a Good Ingredient?

Evidence for visibly strengthening lashes and brows is mostly marketing-driven or small-scale, so results may be subtle, which is why it's rated Fair. Eye-area use can also pose a slight irritation risk for sensitive users.

Products with Biotinoyl Hexapeptide-2 Amide

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