Acetylarginyltryptophyl Diphenylglycine

Acetylarginyltryptophyl diphenylglycine is a lab-made tripeptide derivative of arginine, tryptophan, and diphenylglycine built for cosmetics. It works as a gentle conditioning peptide, supporting comfort and a smoother feel in sensitive-skin formulas.
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Ingredient Snapshot

Overview
A gentle peptide that helps sensitive skin feel calm and smooth.
Category
Skin Conditioning, Sensitive Skin
Type
Peptide

Ingredient Ratings

Overall Rating

Fair

Comedogenic Risk

None

Skin Benefits

May help skin feel calmer and more comfortable while supporting a smoother feel; evidence is preliminary and results can vary. Suitable for routines seeking gentle support without strong actives.

Uses In Skincare & Cosmetics

Often included in lightweight moisturizers, soothing serums, and post-cleanse mists designed for delicate skin.

Comedogenic Rating

This ingredient is not typically evaluated for comedogenicity, and no standardized rating is available.

Safety

Usually low risk, but may cause transient stinging or redness in reactive skin; patch testing is advisable. If you experience sensitivity, avoid combining with potent exfoliants or retinoids.

Is Acetylarginyltryptophyl Diphenylglycine a Good Ingredient?

This one rates Fair due to limited independent clinical evidence for skin benefits, with most support coming from supplier data. Mild irritation is possible in very sensitive skin or when layered with strong actives.